Q. Time series of U.S. economic statistics?

Fraser, The Federal Reserve Archival System for Economic Research, available from the St. Louis Fed includes original documents and press releases including:
 

• Bank Statistics 1896-1955
• Annual Statistical Digest
• Banking and Monetary Statistics 1941-1970
• Business Conditions Digest
• Business Cycle Developments
• Business Statistics (supplement to Survey or Current Business)
• Concordance of Statistics
• Economic Indicators
• Productivity and Costs

The Real Time Data Center from the Federal Reserve Bank of Philadelphia maintains a variety of data sets including the Aruoba-Diebold-Scotti Business Conditions Index, real-time data set for macroeconomists, the Livingston Survey, the Survey of Professional Forecasters, GDPplus, and the Greenbook data sets alllowing one to look at revisions over time.

FRED (Federal Reserve Economic Data), contains the latest version of the data in statistical form.  ALFRED, the Archival Federal Reserve Economic Data, contains the originally published data prior to revisions.

Datastream has point in time data.  Once in Datastream, choose Economics then Explorer, then Point in Time.